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The Daily Leaflets


What you don't know you know
You know what you know. Simple enough. What you don't know you don't know is always a challenge. In between- what you Know you don't know...
Feb 26, 20231 min read


Sine, Cosine, and DNA
Back in high school I had a graphing calculator (long before the age of smartphones… or even cell phones- OMG). It was a Texas...
Feb 25, 20231 min read


Surfing on the AI Hype cycle
I occasionally contemplate where we are on the hype cycle with regards to AI and Pharma. On one hand- the companies developing the tech...
Feb 24, 20232 min read


Insource your knowledge
The further along we go down the development line, the deeper the knowledge we accumulate on the product. This translates to lower risk...
Feb 23, 20232 min read


Time to clean up the Knowledge garage!
Start-ups in pharma are notoriously risky- risks are everywhere, literally. They start with a drug candidate which is 100% uncertain: It...
Feb 22, 20231 min read


Trees, Leaves, and Knowledge
When you map your knowledge, it quickly assumes the shape of a tree.
Feb 21, 20231 min read


We are time
We don't have time. We don't use time. We are time. As we walk through the arrow of time, we accumulate experience, knowledge,...
Oct 3, 20222 min read


Knowledge and Risk
Buddha said: "it is difficult to be thorough in learning and exhaustive in investigation". He was referring, of course, to the arduous...
Sep 1, 20222 min read


The top of the mountain...
We've been climbing the CMC Development mountain in the past few weeks, each session we picked a different track... We spent a great deal...
Jul 7, 20222 min read


The CMC Superhero
The CMC Team: ● Makes sure manufacturing operations are synchronized with clinical needs (be it for clinical trials or market) ● Manages...
Jun 15, 20221 min read


The CMC Train is full steam ahead!
The CMC Essentials Training course is running full steam ahead! Some key take-aways from the first 3 sessions: We discussed how the...
May 31, 20222 min read


To Ph.D or not to Ph.D
When I told my professor in Weizmann I decided not to pursue a Phd, he thought I lost my mind. “Why would you not want to be a...
May 1, 20221 min read


The CMC Triangle
The three cornerstones of CMC: Chemistry, Manufacturing and Controls, are interconnected and impact one another. In this talk, we draw...
Apr 4, 20221 min read


What is CMC?
If you have “CMC” in your job title, your family probably still thinks you’re a chemist of some sort… while that may be true, it neglects...
Mar 13, 20221 min read


A short journey into Pharmaceutical Development
The anticipation for the COVID vaccines brought Pharmaceutical Development to the spotlight as we all witnessed the entire process unfold...
Feb 13, 20221 min read


When risk meets your children
Should we vaccinate our children against COVID-19? What's the difference between deciding for yourself, and deciding for your child, when...
Dec 29, 202111 min read


Pharmaceutical Development, CMC and Beyond!
Would you take a pill for your headache if it made you extremely nauseous? Most likely not. Nevertheless, extreme nausea is a risk people...
Dec 2, 20215 min read


GMP Granola
GMP Granola is my private geeky joke that goes through my head every time I make Granola. In my early Granola making days, I had a...
Dec 2, 20213 min read


Reflection on CMC in the Biotech world
CMC, short for "Chemistry, Manufacturing, Controls", puts Chemistry in the spotlight, but it is our mastering of Biology that brought us...
Nov 1, 20211 min read
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